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Furthermore, through neuroimmune responses, including pro-inflammatory cytokines, excessive alcohol use induces mitochondrial dysfunction

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The ultraviolet rays (UVA) in sunlight can penetrate the dermis of the human skin, affecting the growth of epidermal cells, causing surface cells to age and die, leading to premature aging of the skin, rough and loose skin, pigmentation, etc

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Most information comes from animal studies (where doses are scaled by body weight) and anecdotal reports from users